Area: Discovery, evolution, optimization, characterization and formulation of monoclonal antibodies
Prof. Tessier joined the Rensselaer Polytechnic Institute (New York) in 2007 following a postdoctoral fellowship at the Massachusetts Institute of Technology's Whitehead Institute for Biomedical Research. Prof. Tessier’s research focuses on designing, evolving, optimizing, characterizing and formulating a class of large therapeutic proteins (antibodies) that hold great potential for detecting and treating human disorders ranging from cancer to Alzheimer’s disease. He has received a number of awards in recognition of his pioneering work, including a Humboldt Fellowship for Experienced Researchers (2014-2015), Young Scientist Award from the World Economic Forum (2014), Young Investigator Award from the Biochemical Technology division of the American Chemical Society (2015), Pew Scholar Award in Biomedical Sciences (2010-2014) and National Science Foundation CAREER Award (2010-2015).
Professor Tessier has considerable expertise in discovering, evolving, optimizing, characterizing and formulating therapeutic proteins such as monoclonal antibodies for diverse applications. He has worked with many biotech companies to address a range of challenges from antibody discovery to formulation and delivery. He has also published many influential scientific articles regarding his pioneering research. He has published multiple articles in Nature, one of the premier science journals. He also developed a new approach for designing antibodies that can be used to target toxic protein aggregates associated with Alzheimer's and Parkinson's disease. Moreover, he has developed new high-throughput screening methods for characterizing the biophysical properties of antibodies as well as protein engineering methods to improve antibody solubility.
Honors and Awards:
• Young Investigator Award, Division of Biochemical Technology, American Chemical Society, 2015
• Alexander von Humboldt Fellowship for Experienced Researchers, 2014-present
• Young Scientist Award, World Economic Forum, 2014
• National Science Foundation CAREER Award, 2010-2015
• Pew Scholar Award in Biomedical Sciences, 2010-2015
• Rensselaer School of Engineering Teaching Excellence Award, 2013
• Rensselaer Early Career Award, 2012
• Rensselaer School of Engineering Research Excellence Award, 2012
• American Cancer Society Postdoctoral Fellowship, 2004-2007
• NASA Graduate Research Fellowship, 1999-2002
• Semi-Finalist, Discover Magazine Award for Tech. Innovation, 2000
• Sule, S.V., Dickinson, C.G., Lu, J., Chow, C.-K., Tessier, P.M., “Rapid analysis of antibody self-association in complex mixtures using immunogold conjugates”, Mol Pharm, 10, 1322 (2013).
• Tiller, K.E., Tessier, P.M.,“Advances in antibody design”, Ann Rev Biomed Eng, (2015).
• Lee, C., Perchiacca, J.M., Tessier, P.M., “Toward aggregation-resistant antibodies by design”, Trends Biotechnol, 31, 612 (2013).
• Perchiacca, J.P., Ladiwala, A.R.A, Bhattacharya, M.B., Tessier, P.M., "Structure-based design of conformation- and sequence-specific antibodies against amyloid β", P Natl Acad Sci U S A, 109, 84 (2012).
• Perchiacca, J.M., Ladiwala, A.R.A., Bhattacharya, M., Tessier, P.M., "Aggregation-resistant domain antibodies engineered with charged mutations near the edges of the complementarity-determining regions", Protein Eng Des Sel, 12, 591 (2012).
• Geng, S.B., Cheung, J.K., Narasimhan, C., Shameem, M., Tessier, P.M.,* “Improving monoclonal antibody selection and engineering using measurements of colloidal protein interactions”, J Pharm Sci, 103, 3356 (2014)
• 2014—present, Richard Baruch M.D. Career Development (Endowed) Associate Professor of Chemical and Biological Engineering, Rensselaer Polytechnic Institute
• 2014—present, Humboldt Fellow, Max Planck Institute for Biochemistry
• 2013—2014, Associate Professor of Chemical and Biological Engineering, Rensselaer Polytechnic Institute
• 2007—2013, Assistant Professor of Chemical and Biological Engineering, Rensselaer Polytechnic Institute
• B.S., Univ. of Maine, 1994-1998
• Ph.D., Univ. of Delaware, 1998-2003
• Postdoctoral Fellowship, Whitehead Institute for Biomedical Research (MIT), 2003-2007
• Prof. Tessier holds one patent under his name registered in 2005:
• Lindquist S.L., Krishnan R., Tessier P.M., “Devices from prion-like proteins”, US Patent 60/689783